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FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Quetiapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using quetiapine. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking quetiapine, do not stop taking it without your doctors advice. Do not give quetiapine to a child without a doctors advice. Extended-release quetiapine Seroquel XR is for use only in adults and should not be given to anyone younger than 18 years old.
The total daily dose for the initial five days of therapy is 50 mg Day 1, 100 mg Day 2, 200 mg Day 3, 300 mg Day 4 and 400 mg Day 5. After Day 5, the dose should be adjusted within the recommended dose range of 400 to 600 mg/day based on response and tolerability. Dosage adjustments should be in increments of no greater than 100 mg/day. Efficacy was demonstrated with Seroquel at both 400 mg and 600 mg; however, no additional benefit was seen in the 600 mg group.
Seizures: Quetiapine should be used cautiously in patients with a history of seizures or with conditions that potentially lower the seizure threshold, eg, Alzheimer-s dementia.
For Adults: for adults the dose is 100mg per day on the first day and that is in case of monotherapy or adjunct therapy. The dose can be increased up to 400mg per day and that is to be done on the fourth day. The increments that are required to be made are of 100mg per day and that is twice on daily basis. Clinical studies have shown that the patients have responded the best for the doses of around 400mg per day to 800mg per day. Again for bipolar disorder like schizophrenia, the clinical trials have not been conducted for the dosages above 800mg per day.
Mania Mania causes you to feel abnormally and persistently happy, angry, hyperactive, impulsive, and irrational at different times. These feelings last at least one week, and may be severe enough that you need to be treated in a hospital. Other symptoms may include:
Patients often have more than one medical problem and need different drugs to treat each condition. Such medications may interact with drugs used to treat bipolar disorder or increase side effects. For example, children with bipolar disorder have a higher risk for attention deficit-hyperactivity disorder, which is treated with stimulants that can complicate bipolar treatment.
Patients should avoid anti-anxiety drugs, alcohol, caffeine, and stimulants.
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Following or in lieu of a hospital admission, support services available can include drop-in centers, visits from members of a community mental health team or Assertive Community Treatment team, supported employment and patient-led support groups, intensive outpatient programs. These are sometimes referred to partial-inpatient programs.
Schizophrenia is a serious mental illness that manifests in altered thinking, impaired perceptions of reality, hallucinations, and bizarre behaviour. One type
Other investigators are studying the effects of glycine, a common amino acid, which stimulates receptors in the brain that are impaired in schizophrenia. In small studies, large doses of glycine resulted in a small improvement in negative symptoms in some patients. Researchers, however, are more interested in agents called glycine transport inhibitors, which would elevate glycine levels in the brain, and would therefore have a more potent effect.Glycine itself is available in health stores, but such products are unlikely to have much effect.
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